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KMID : 1034320150060020081
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Sleep Medicine Research
2015 Volume.6 No. 2 p.81 ~ p.83
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Post-Traumatic Narcolepsy Associated with Thalamic/Hypothalamic Injury
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:Yi Ki-Kyoung
:Chung Seock-Hoon/:Park Bo-Ram/:Kim Jong-Sung
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Abstract
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The hypothalamus is an important structure that regulates sleep via hypocretin neurotransmission. Central nervous system disorders such as tumors and vascular legions involving the hypothalamus can cause secondary narcolepsy. In addition, brain trauma can contribute to post-traumatic narcolepsy despite lack of any definite brain lesion. Here, we present a case of a 37-year-old man suffering from a hypothalamus-to-thalamus hemorrhage after a traffic accident. After this trauma, he suffered from excessive daytime sleepiness and was diagnosed with post-traumatic narcolepsy by polysomnography and multiple sleep latency tests. He was positive for human leukocyte antigen (HLA)-DQB1*03:01 and HLA-DQB1*06:01 antigens.
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KEYWORD
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Narcolepsy, Brain hemorrhage, Traumatic, HLA-DQB1*0601
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